Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.

When her insurance company refuses to approve the care her husband needs to survive, Sonia Bonet (Jan Raluy) takes things into her own hands. Up against an unyielding bureaucracy and disinterested workers, she is pushed to her breaking point: with her son in tow, she attempts to fight the system.